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ADVANCED HEMATOPATHOLOGY • 2026

Advanced Diagnostic
Hematopathology

An advanced case-based course integrating morphology, immunophenotyping,
molecular testing and genomic technologies for challenging myeloid
and lymphoid disorders.


APRIL 9, 2026


VIDEOS


PDFs



THE MODERN DIAGNOSTIC CHALLENGE

How Do We Turn Complex Molecular Data
Into an Accurate Hematopathology Diagnosis?

Our understanding of the molecular pathogenesis of hematopoietic and lymphoid
tumors has advanced significantly. Next-generation technologies now allow
increasingly precise interrogation of tumor genomes and are moving personalized
medicine closer to routine clinical practice.

At the same time, the increasing volume and complexity of diagnostic information
requires pathologists to continuously reassess disease definitions,
classification criteria and testing strategies.

Modern hematopathology therefore depends on the
integration of morphology, immunophenotypic studies,
molecular findings and genetic data
rather than interpretation
of any individual test in isolation.



THE INTEGRATED DIAGNOSTIC WORKUP

From Specimen → to Integrated Diagnosis

01 • MORPHOLOGY

Recognize the Pattern

Evaluate morphologic findings and establish the initial diagnostic framework.

02 • IMMUNOPHENOTYPE

Characterize the Proliferation

Select and interpret appropriate ancillary immunophenotypic studies.

03 • MOLECULAR TESTING

Interrogate the Disease

Use molecular methodologies to investigate diagnostically relevant abnormalities.

04 • GENOMIC DATA

Refine Classification

Incorporate emerging genomic technologies into difficult diagnostic workups.

05 • INTEGRATED INTERPRETATION

Reach the Diagnosis

Combine morphologic and ancillary findings to establish an accurate,
clinically meaningful diagnosis.



COURSE OVERVIEW

Complex Disorders. Practical Diagnostic Approaches.

This long course addresses important knowledge gaps and challenging diagnostic
scenarios involving selected myeloid and lymphoid disorders.

Each lecture is paired with case-based diagnostic examples
designed to demonstrate practical and comprehensive approaches to difficult
hematopathology workups.

The curriculum spans common and unusual
myeloid, histiocytic, B-cell and T-cell proliferations,
with particular attention to appropriate immunophenotypic and genetic testing strategies.



DIAGNOSTIC SPECTRUM

Four Major Areas of Hematopathology

01


MYELOID NEOPLASMS

Review challenging myeloid disorders, including pediatric
myelodysplastic syndromes/neoplasms and their differential diagnosis.

02


B-CELL NEOPLASMS

Explore diagnostic approaches to high-grade and splenic B-cell lymphomas,
including classification challenges.

03


T-CELL LYMPHOMAS

Examine advances in peripheral T-cell lymphomas and their evolving
diagnostic landscape.

04


HISTIOCYTIC & DENDRITIC NEOPLASMS

Review new concepts and molecular insights relevant to these uncommon
and diagnostically challenging neoplasms.



MOLECULAR HEMATOPATHOLOGY

Beyond Morphology

Emerging technologies are reshaping how hematopoietic and lymphoid
neoplasms are investigated and classified.

NEXT-GENERATION TECHNOLOGIES

Understand new genomic technologies relevant to contemporary diagnostic hematopathology.

ADVANCED MOLECULAR TESTING

Explore how advanced molecular studies can support more accurate and comprehensive diagnoses.

PRACTICAL TEST SELECTION

Consider cost-effective application of advanced testing across different practice settings.

INTEGRATED INTERPRETATION

Connect ancillary findings with morphologic and clinical information
to resolve difficult diagnostic scenarios.



LEARNING OBJECTIVES

What You’ll Learn


Apply Current Diagnostic Criteria

Review current diagnostic criteria for selected challenging B-cell,
T-cell, histiocytic/dendritic and myeloid neoplasms affecting adults and children.


Understand Emerging Molecular Technologies

Discover technologies enabling increasingly accurate and comprehensive
hematopathology diagnosis.


Use Testing More Practically

Learn cost-effective approaches to advanced molecular testing
across different diagnostic practice settings.


Solve Complex Diagnostic Scenarios

Develop integrated approaches to difficult cases using ancillary testing
and comprehensive interpretation.



COURSE PROGRAM

Lectures & Diagnostic Topics

LECTURE 01 • MOLECULAR DIAGNOSTICS

Novel Genomic Technologies in Hematopathology:
A Primer for the Diagnostic Pathologist

Rashmi Kanagal-Shamanna, MD

LECTURE 02 • HISTIOCYTIC / DENDRITIC

New Concepts in Histiocytic/Dendritic Neoplasms

Jean-Francois Emile, MD, PhD, APHP

LECTURE 03 • PEDIATRIC MYELOID

Pediatric Myelodysplastic Syndromes/Neoplasms
and Their Differential Diagnosis

Jacob Bledsoe, MD

LECTURE 04 • B-CELL

Approach to the Diagnosis of High-Grade B-Cell Lymphomas

Lisa Rimsza, MD

LECTURE 05 • T-CELL

Advances in Peripheral T-Cell Lymphomas

Megan Lim, MD, PhD

LECTURE 06 • SPLENIC B-CELL

A Roadmap for the Classification of Splenic B-Cell Lymphomas

Sarah Ondrejka, DO

INTERACTIVE SESSION

Q&A



CASE-BASED EDUCATION

Not Just Classification.
Diagnostic Problem Solving.

Each lecture is paired with diagnostic case examples designed to demonstrate
practical approaches to challenging hematopathology workups.

01 — Define the Diagnostic Problem
02 — Build the Differential Diagnosis
03 — Select Appropriate Ancillary Tests
04 — Interpret Molecular & Immunophenotypic Findings
05 — Integrate the Findings Into the Final Diagnosis



TARGET AUDIENCE

Who Is This Course For?

Designed for pathologists seeking advanced education in the diagnosis
and workup of hematopoietic and lymphoid neoplasms.

Practicing Academic Pathologists
Community Pathologists
Pathologists-in-Training



WHY THIS COURSE?

Modern Hematopathology Requires
More Than Morphology Alone

Disease definitions and diagnostic criteria continue to evolve as molecular
knowledge expands and increasingly sophisticated technologies become available.

The challenge is not simply obtaining more data—it is understanding
which tests to use, when to use them,
and how to integrate their results
into a coherent diagnosis.

✓ Review challenging disease classifications
✓ Understand emerging genomic technologies
✓ Improve ancillary testing strategies
✓ Apply molecular testing more practically
✓ Strengthen integrated diagnostic interpretation



COURSE CONTENT

Included With This Course


▶ Video Lectures

Advanced educational lectures covering challenging hematopathology topics.


▤ Course PDFs

Supporting PDF educational materials included with the course.



ADVANCED HEMATOPATHOLOGY • 2026

Recognize the Pattern.
Interrogate the Biology.
Integrate the Diagnosis.

A case-based educational course exploring challenging myeloid,
histiocytic, B-cell and T-cell disorders through modern molecular
testing and integrated diagnostic interpretation.

VIDEOS   •   PDFs   •   APRIL 2026

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